Therapeutic production in Escherichia coli using retrosynthetic design of metabolic pathways | ESF-EMBO Symposium Synthetic Biology of Antibiotic Production

Anne-GaĆ«lle Planson (Selected oral presentation) – Therapeutic production in Escherichia coli using retrosynthetic design of metabolic pathways

Thursday 6 October, 2011

ESF-EMBO Symposium Synthetic Biology of Antibiotic Production

This conference will focus on the advancement of synthetic biology, especially its application in the field of antibiotic production in filamentous fungi and actinomycete bacteria, including the implementation and modification of complex biosynthesis pathway modules in existing and new production hosts. Antibiotics production is regulated by complex networks and involves intricate multi-step biosynthetic machineries, as well as major reorganization of primary metabolic fluxes to redirect cellular metabolic resources towards their biosynthesis. The urgent need for new antibiotics caused by the accelerating emergence of multi-drug resistant pathogens worldwide has led to a strong interest in the research community for decidedly novel approaches, collectively referred to as Synthetic Biology.