Determinants of protein affinity and promiscuity for in-silico engineering of biological circuits and devices | LRI Seminars

Determinants of protein affinity and promiscuity for in-silico engineering of biological circuits and devices
Pablo Carbonell
LRI Laboratory for Computer Science Seminars, Université Paris-Sud, Orsay (France),
17 March 2011 14h – 17 March 2011 15h, Salle/Bat : 101/490

Identifying determinants of specificity and affinity in protein-ligand and protein-protein interactions is central to the development of robust and reliable biological circuits and devices, such as synthetic metabolic networks, biosensors, and signaling pathways. In this talk, we present large-scale machine learning-based approaches to identifying descriptors in the chemical, sequence, and structure space of biological networks playing a role modulating protein interactions.