Compound toxicity in bacteria plays a major role in synthetic biology and metabolic engineering as well as in the development of new antibacterial agents. Here, we screened a diversified chemical library of 166 compounds for toxicity in Escherichia coli. The…
We have developed a unified framework that integrates in a web server diverse techniques involved in the design of heterologous biosynthetic pathways through a retrosynthetic approach in the reaction signature space (see XTMS). To access to the RetroPath web server…
The Promis Server is a web-based implementation of our method to predict catalytic and substrate promiscuity on enzyme sequences at residue level by using Support Vector Machines trained on molecular signatures. Note: the server Promis has moved to abSYNTH, the…
Canonical signatures are representations of the local structure of molecules. Their canonical-height version gives a global description of the structure. Canonical representations fully identify molecules. We introduce a web server that computes the signature for a given chemical compound. Note:…